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Post by tcranch on Jan 13, 2020 7:11:58 GMT -6
Gotta be honest, Raven. MLV's scare me but most likely because I've never used them although retained heifers get a MLV when they're BANGS/pelvic measured - by the vet. Don't be scared. A lot of the fear is hype. Nevertheless, killed vaccines are effective. Well, you know I almost switched last year. But another reason is more of a time management issue. Prior to working cattle I spend quality time pre-filling all the (disposable) syringes. They're separated by vaccine, cow/calf/pasture and in individual coolers so when we're running them through the chute I'm on one side, a crew member on the other, one-n-done. No stopping to switch needles, re-fill, mix, etc and it saves a good hour. I've been referred to as the Anal Poster Child (but I've been called worse!)  |
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Post by brightraven on Jan 13, 2020 7:28:42 GMT -6
Don't be scared. A lot of the fear is hype. Nevertheless, killed vaccines are effective. Well, you know I almost switched last year. But another reason is more of a time management issue. Prior to working cattle I spend quality time pre-filling all the (disposable) syringes. They're separated by vaccine, cow/calf/pasture and in individual coolers so when we're running them through the chute I'm on one side, a crew member on the other, one-n-done. No stopping to switch needles, re-fill, mix, etc and it saves a good hour. I've been referred to as the Anal Poster Child (but I've been called worse!) 😀😀😀😀😀😀 You identified the primary disadvantage to MLV. Timing! It is not as convenient as being able to vaccinate at any time! |
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Post by the illustrious potentate on Jan 17, 2020 4:16:17 GMT -6
Do we know what a 'good' titer is? Or, if any particular titer is actually indicative of adequate protection? What about pathogens/vaccines that elicit or depend more upon a cell-mediated immune response or mucosal secretory antibody response than a humoral antibody response? How much does immunity to specific pathogens depend upon circulating antibody versus immune 'memory' cells primed to respond upon subsequent reexposure? I doubt that just bleeding a random animal here and there and checking titers is going to give you really meaningful information about whether your animals are 'protected', just that their immune system has 'seen' a particular antigen at some point - and it may not accurately reflect actual herd immunity. Not putting words in LuckyP's mouth, but here's a pretty good video touching on the subject of how vaccination/antibodies fits into overall immunity. It's a broad subject, but this guy gives a pretty good overview and is worth a little time. The speaker talks about the brain in the gut here as well, and that is pretty fascinating to me also. PBS had a great documentary on the whole system several years ago. It's a little off topic here, but pretty amazing how much communication exists and how much it affects overall health. |
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Post by brightraven on Jan 17, 2020 6:06:44 GMT -6
Do we know what a 'good' titer is? Or, if any particular titer is actually indicative of adequate protection? What about pathogens/vaccines that elicit or depend more upon a cell-mediated immune response or mucosal secretory antibody response than a humoral antibody response? How much does immunity to specific pathogens depend upon circulating antibody versus immune 'memory' cells primed to respond upon subsequent reexposure? I doubt that just bleeding a random animal here and there and checking titers is going to give you really meaningful information about whether your animals are 'protected', just that their immune system has 'seen' a particular antigen at some point - and it may not accurately reflect actual herd immunity. Not putting words in LuckyP's mouth, but here's a pretty good video touching on the subject of how vaccination/antibodies fits into overall immunity. It's a broad subject, but this guy gives a pretty good overview and is worth a little time. The speaker talks about the brain in the gut here as well, and that is pretty fascinating to me also. PBS had a great documentary on the whole system several years ago. It's a little off topic here, but pretty amazing how much communication exists and how much it affects overall health. Fundamentally, the concept is presented like it was 50 years ago. That is a fine presentation to watch. Thanks. |
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