Post by TIP on Oct 22, 2022 16:33:59 GMT -6
Posting this here to make it easier for people to reference since this is getting more public attention.
I had colon cancer that was successfully treated with the following protocol. Fenbendazol alone wasn't successful in treatment for me. But I also didn't use it in combination with fasting or with as extensive of supplements.
I tried to attach a few references to substantiate why I incorporated various things. But there's a ton of information if you start getting into NIH studies and certain websites that cache studies on non-traditional treatment. I can't find the one I thought the most beneficial, but if I come across it again, I'll post it.
There are two ways cells generate energy- respiration or glycolysis. Based on the work at USC on fasting,a major goal of what I did was to force the cancer cells into respiration and away from glycolysis energy production. In respiration, you can target the cells with oxidative agents in their mitochondria. Okie on here got me started looking into the fasting aspect after someone else was successful in treating colon cancer using it. I'll provide some links to the mechanisms of why it works.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6441206/
I used fasting or near fasting diet to push myself into that state. Doing so, all cells but the cancer cells decrease metabolism. So any oxidative injury is minimalized to the other cells. 72 hours appears necessary to put your body into that state. I ate only 1 meal a day for 2 days, then went about 4 days, then went back to one meal a day for 2 days. I then just limited what I ate for a while and cut out all simple carbohydrates. There are probably better protocols with a simple search.
But fasting resets the immune system as well. It can reactivate it against cancer cells that it has learned to ignore.
news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/
news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/
Helps target oxidative injury
news.usc.edu/170125/fasting-mimicking-diet-vitamin-c-cancer-treatment-usc-research/
Vitamin C
The daily supplement need increases with disease. The body absorbs more.
Can cause GI disturbance if not being absorbed in higher doses. Down side is without adequate hydration, increase chance of urinary calculi. But I took 5 to 7k mg a day while I felt the worst and then about 2-3 k when I felt better.
Ivermectin
I took 0.45 mg/kg (2 mls per 100 lbs) a day for a month. I don't have all the safety trial information handy, but I saw up to 0.8 mg/kg used with only side effect of blurry vision reported. I did have slight blurry vision once when I inadvertently dosed myself twice in one day. But it was short lived- less than a day. I didn't need to continue longer than a month.
Reversal of chemo resistance is reported, but I believe that Ivermectin is the primary agent that's having anticancer effect in many of these cases and they're giving the other agents the credit. Ivermectin isn't patentable, the others are. When looking at the studies, they aren't running ivermectin by itself as a control that I've seen.
pubmed.ncbi.nlm.nih.gov/31215501/
I think it has multiple mechanisms of action.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6982461/
Vitamin D3- I was severely deficient and took 5k SID but increased to 10k IU SID as 5K wasn't sufficient based on serum levels.
Levels should be measured. Most people are severely low. Lots of studies on D3 and anticancer effects. Part of which it is necessary for proper immune function. It also reduces inflammation.
www.webmd.com/cancer/news/20111004/low-vitamin-d-levels-linked-to-advanced-cancers
Artemisia (sweet wormwood) Oxidative agent.
I know of no studies using this in combination with all I used, but I was about to check out and didn't mind taking chances. I know that there is an ongoing study of HCQ with ivermectin, but it's still ongoing I believe.
Work being done in Kentucky University - just a general discussion of their interest in it.
This botonist talks about his thoughts that utilizing the plant likely has synergistic properties vs the isolated artemisinin. I think he's likely correct from other sources I found at the time as well.
I used the following at 10 mg/kg divided BID so ~ 600 mg BID in pulse therapy.
www.amazon.com/Solaray-Sweet-Wormwood-Aerial-VCapsules/dp/B001L7X1BQ/ref=sr_1_3_mod_primary_new?crid=M57RRD6A8KA4&keywords=sweet+annie+capsules&qid=1640146796&sbo=RZvfv%2F%2FHxDF%2BO5021pAnSA%3D%3D&sprefix=sweet+annie+capsule%2Caps%2C120&sr=8-3
www.ncbi.nlm.nih.gov/pmc/articles/PMC6102173/
www.canceractive.com/article/artemisinin-anticancer%20protocol
The Artemisinin anti-cancer protocol
In human experiments the Singh team used a reduced carbohydrate diet with vitamin D supplementation (5,000IUs) and encouraged exercise. Artemisinin can cross the blood brain barrier.
Singh believes that plant iron from a plant-based diet and supplements such as Floradix, provides ferric iron. By providing 1 gm of vitamin C (with a little oil) after meals, the ferric iron converted to ferrous iron in the cancer cell and thus the vitamin C encourages greater uptake.
The Artemisinin should be given on an empty stomach but with a little yoghurt (which contains no iron) to help absorption, and before bed as the immune system falls at night and cancer cells proliferate more.
Dose is 100 mg of artemisinin supplement per 10 kg of body weight.
Some practitioners believe it should be taken with 1000 mg of cod liver oil, and 3 gm of Conjugated Linoleic Acid.
It is sometimes observed that the body becomes ‘used to’ artemisinin and the herb under-performs. For this reason some practitioners ‘pulse’ the herb – 5 days on, 3 off; or 8 days on, 3 off.
Please Note:
The protocol should not be used by smokers, people having radiotherapy, or people taking glutathione. None of these should have been used in the previous 6 months. Caution is urged by CANCERactive, if a patient has impaired liver function.
Plasma levels are higher in women than men, and peak after 90 minutes.
Singh uses the treatment for up to a year.
As I stated at the top, I used a higher dose of Vitamin C.
Alpha lipoic acid- as noted directly above, conjugated LA it is recommended to be used in that protocol. But it has antineoplastic properties on it's own- exception I believe was prostate cancer if I remember correctly it might have a negative correlation. There was a reason I used ALA and not just LA, but I can't recall the specifics of why off the top of my head at the moment. As stated in link below, Vit E may decrease some of the oxidative effects, but I suspected the benefits outweighed that based on numerous protocols utilizing vitamin E.
pubmed.ncbi.nlm.nih.gov/9489490/
Colloidal silver- it is the most off the beaten path thing I used. I do believe it is beneficial, but it's probably the thing that gets the most resistance to conventional therapy.
It has had a little mainstream media acknowledgement.
www.dailymail.co.uk/health/article-2095610/Silver-bullet-cancer-Metal-kill-tumours-better-chemotherapy-fewer-effects.ht
The following site does a pretty good job of having accumulated references.
www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/
(If anyone is trying to fight hard to target cancer, I suspect some of the nanoparticle therapies would be something to think about/look into.)
From the above referenced website:
Anti Cancer Mechanisms
"ROS generations: Trigger mitochondria-mediated apoptosis by increasing ROS production and decreasing ATP generation: cell death is initiated by entry of AgNPs into the cells, which then triggers ROS production, LDH leakage, increase of pro-oxidants, and decrease of antioxidants, which leads to cytotoxicity. Altering of mitochondrial membrane potential (MMP) subsequently results in the release of pro-apoptotic mitochondrial proteins into the cytosol. This activates caspase-dependent processes culminating in cell death. Loss of MMP hampers mitochondrial function, which triggers a bio-energetic crisis due to loss of ATP. Depending on the intensity of the mitochondrial insult, the cell can undergo apoptosis, necrosis, and/or autophagic cell death, such as accumulation of autophagosomes (Ref.)"
.
"Anti-angiogenesis (new blood vessels formation inhibitor): While going through a case report of a lady who ingested an extreme amount of silver particels experiencing argyria, I found interesting that all her blood analysis came out well, with the exception of the serum silver concentration that was 381 ng/ml (reference value <15 ng/ml) while her serum copper level was 24.8 mg/dl (normal range 70.0–155.0 mg/dl), and serum ceruloplasmin was 9.0 mg/dl (normal range 17.9–53.3 mg/dl). As we discussed here, Copper is essential for angiogenesis and tumor growth and Copper depleting treatments can be effective anti cancer treatments (Ref.). Indeed, after searching through the literature, I found more case reports where high ingestion of silver nanoparticles leads to copper and caeruloplasmin deficiency (Ref.1, Ref.2). This is why silver solutions may also be effective against ascites (Ref.)."
"Here I also found a paper reporting that Silver nanoparticles can act as an angiogenessis inhibitor, but the authors did not connect that with silver influence on copper metabolism but with HIF-1 modulation (Ref.). Digging further in literature we find that indeed it is known that Silver inhibits Copper transport (Ref.)."
.
"This is a similar effect as that of Tetrathiomolybdate www.cancertreatmentsresearch.com/tetrathiomolybdate-tm/, a Copper depleting substance with known anticancer effects. Actually Copper and Silver use the same transporter (CTR1 or copper transporter 1) when is absorbed in the body. And when used in higher amounts Silver is known to inhibit that www.sciencedirect.com/science/article/pii/S0946672X10000106 In turn, CTR1 silencing inhibits Angiogenesis by limiting copper entry into the cells journals.plos.org/plosone/article?id=10.1371/journal.pone.0071982"
.
"Autophagy disruption (Ref.)
.
Killing intratumoral bacteria – see explanation and references at the end of the Background section, above
.
Multi Drug Resistance (MDR1) inhibition to increase/enable effectiveness of chemotherapy (Ref.) – for this purpose, larger nano particles (about 75nm) are more efficient than the small ones
.
Inducing Endoplasmic reticulum (ER) stress (Ref.)
Toxicity and Side Effects
Research suggests that the generation of ROS is the mechanism underlying the cytotoxicity of silver nanoparticles (Ref.)."
"Silver was cleared from most organs after 8 weeks, but there is a longer retention of silver in brain and testis that should be considered in a risk assessment of silver nanoparticles (Ref.). Indeed, it has been shown that following the administration of silver nanoparticles, the anti-oxidant production inside the cells increases (via the activation of Nrf2 pathway – I discussed this pathway and its modulators sometimes ago here) (Ref.). On this line, if a patient uses high doses of Silver nanoparticles, he/she should be pay attention to the other pro-oxidant treatments used (such as chemo) since using more proxidant treatments at the same time may increase the risk of side effects.
Given the main mechanism leading to side effects indicated in the literature, I would always make sure to have strong anti oxidants at home, such as NAC (supplement available on-line) and use it if side effects are present during the use of silver nanoparticles.
Supplementation with Selenium or Vitamin E has been shown to increase the maximum acceptable exposure to silver (Ref.)."
pubmed.ncbi.nlm.nih.gov/23811290/
6.8µg/kg dose seems to be a safe dose.
I took colloidal silver regularly for about a week and then once to twice weekly.
I also took Vitamin E with Selenium daily. 268 mg SID
I think the antibacterial effects should not be overlooked on silver also.
www.nature.com/articles/srep14554
Zinc- 30 mg SID And I utilized zinc to promote natural killer cell immunity.
pubmed.ncbi.nlm.nih.gov/20155630/
Vitamin A- 1500 mcg (5000 IU) SID
Immune support
Vitamin K2 I took 100 mcg SID
pubmed.ncbi.nlm.nih.gov/29805627/
B Complex- I took twice recommended daily dosage as excess will be eliminated like Vitamin C.
Immune system function
CBD- full spectrum 1500 mg CBD SID
Cannabinoid system is overlooked. Has primary effect on cancer cells, controls nausea, reduced inflammation.
pubmed.ncbi.nlm.nih.gov/30627539/
I had colon cancer that was successfully treated with the following protocol. Fenbendazol alone wasn't successful in treatment for me. But I also didn't use it in combination with fasting or with as extensive of supplements.
I tried to attach a few references to substantiate why I incorporated various things. But there's a ton of information if you start getting into NIH studies and certain websites that cache studies on non-traditional treatment. I can't find the one I thought the most beneficial, but if I come across it again, I'll post it.
There are two ways cells generate energy- respiration or glycolysis. Based on the work at USC on fasting,a major goal of what I did was to force the cancer cells into respiration and away from glycolysis energy production. In respiration, you can target the cells with oxidative agents in their mitochondria. Okie on here got me started looking into the fasting aspect after someone else was successful in treating colon cancer using it. I'll provide some links to the mechanisms of why it works.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6441206/
I used fasting or near fasting diet to push myself into that state. Doing so, all cells but the cancer cells decrease metabolism. So any oxidative injury is minimalized to the other cells. 72 hours appears necessary to put your body into that state. I ate only 1 meal a day for 2 days, then went about 4 days, then went back to one meal a day for 2 days. I then just limited what I ate for a while and cut out all simple carbohydrates. There are probably better protocols with a simple search.
But fasting resets the immune system as well. It can reactivate it against cancer cells that it has learned to ignore.
news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/
news.usc.edu/63669/fasting-triggers-stem-cell-regeneration-of-damaged-old-immune-system/
Helps target oxidative injury
news.usc.edu/170125/fasting-mimicking-diet-vitamin-c-cancer-treatment-usc-research/
Vitamin C
The daily supplement need increases with disease. The body absorbs more.
Can cause GI disturbance if not being absorbed in higher doses. Down side is without adequate hydration, increase chance of urinary calculi. But I took 5 to 7k mg a day while I felt the worst and then about 2-3 k when I felt better.
Ivermectin
I took 0.45 mg/kg (2 mls per 100 lbs) a day for a month. I don't have all the safety trial information handy, but I saw up to 0.8 mg/kg used with only side effect of blurry vision reported. I did have slight blurry vision once when I inadvertently dosed myself twice in one day. But it was short lived- less than a day. I didn't need to continue longer than a month.
Reversal of chemo resistance is reported, but I believe that Ivermectin is the primary agent that's having anticancer effect in many of these cases and they're giving the other agents the credit. Ivermectin isn't patentable, the others are. When looking at the studies, they aren't running ivermectin by itself as a control that I've seen.
pubmed.ncbi.nlm.nih.gov/31215501/
I think it has multiple mechanisms of action.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6982461/
Vitamin D3- I was severely deficient and took 5k SID but increased to 10k IU SID as 5K wasn't sufficient based on serum levels.
Levels should be measured. Most people are severely low. Lots of studies on D3 and anticancer effects. Part of which it is necessary for proper immune function. It also reduces inflammation.
www.webmd.com/cancer/news/20111004/low-vitamin-d-levels-linked-to-advanced-cancers
Artemisia (sweet wormwood) Oxidative agent.
I know of no studies using this in combination with all I used, but I was about to check out and didn't mind taking chances. I know that there is an ongoing study of HCQ with ivermectin, but it's still ongoing I believe.
Work being done in Kentucky University - just a general discussion of their interest in it.
This botonist talks about his thoughts that utilizing the plant likely has synergistic properties vs the isolated artemisinin. I think he's likely correct from other sources I found at the time as well.
I used the following at 10 mg/kg divided BID so ~ 600 mg BID in pulse therapy.
www.amazon.com/Solaray-Sweet-Wormwood-Aerial-VCapsules/dp/B001L7X1BQ/ref=sr_1_3_mod_primary_new?crid=M57RRD6A8KA4&keywords=sweet+annie+capsules&qid=1640146796&sbo=RZvfv%2F%2FHxDF%2BO5021pAnSA%3D%3D&sprefix=sweet+annie+capsule%2Caps%2C120&sr=8-3
www.ncbi.nlm.nih.gov/pmc/articles/PMC6102173/
www.canceractive.com/article/artemisinin-anticancer%20protocol
The Artemisinin anti-cancer protocol
In human experiments the Singh team used a reduced carbohydrate diet with vitamin D supplementation (5,000IUs) and encouraged exercise. Artemisinin can cross the blood brain barrier.
Singh believes that plant iron from a plant-based diet and supplements such as Floradix, provides ferric iron. By providing 1 gm of vitamin C (with a little oil) after meals, the ferric iron converted to ferrous iron in the cancer cell and thus the vitamin C encourages greater uptake.
The Artemisinin should be given on an empty stomach but with a little yoghurt (which contains no iron) to help absorption, and before bed as the immune system falls at night and cancer cells proliferate more.
Dose is 100 mg of artemisinin supplement per 10 kg of body weight.
Some practitioners believe it should be taken with 1000 mg of cod liver oil, and 3 gm of Conjugated Linoleic Acid.
It is sometimes observed that the body becomes ‘used to’ artemisinin and the herb under-performs. For this reason some practitioners ‘pulse’ the herb – 5 days on, 3 off; or 8 days on, 3 off.
Please Note:
The protocol should not be used by smokers, people having radiotherapy, or people taking glutathione. None of these should have been used in the previous 6 months. Caution is urged by CANCERactive, if a patient has impaired liver function.
Plasma levels are higher in women than men, and peak after 90 minutes.
Singh uses the treatment for up to a year.
As I stated at the top, I used a higher dose of Vitamin C.
Alpha lipoic acid- as noted directly above, conjugated LA it is recommended to be used in that protocol. But it has antineoplastic properties on it's own- exception I believe was prostate cancer if I remember correctly it might have a negative correlation. There was a reason I used ALA and not just LA, but I can't recall the specifics of why off the top of my head at the moment. As stated in link below, Vit E may decrease some of the oxidative effects, but I suspected the benefits outweighed that based on numerous protocols utilizing vitamin E.
pubmed.ncbi.nlm.nih.gov/9489490/
Colloidal silver- it is the most off the beaten path thing I used. I do believe it is beneficial, but it's probably the thing that gets the most resistance to conventional therapy.
It has had a little mainstream media acknowledgement.
www.dailymail.co.uk/health/article-2095610/Silver-bullet-cancer-Metal-kill-tumours-better-chemotherapy-fewer-effects.ht
The following site does a pretty good job of having accumulated references.
www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/
(If anyone is trying to fight hard to target cancer, I suspect some of the nanoparticle therapies would be something to think about/look into.)
From the above referenced website:
Anti Cancer Mechanisms
"ROS generations: Trigger mitochondria-mediated apoptosis by increasing ROS production and decreasing ATP generation: cell death is initiated by entry of AgNPs into the cells, which then triggers ROS production, LDH leakage, increase of pro-oxidants, and decrease of antioxidants, which leads to cytotoxicity. Altering of mitochondrial membrane potential (MMP) subsequently results in the release of pro-apoptotic mitochondrial proteins into the cytosol. This activates caspase-dependent processes culminating in cell death. Loss of MMP hampers mitochondrial function, which triggers a bio-energetic crisis due to loss of ATP. Depending on the intensity of the mitochondrial insult, the cell can undergo apoptosis, necrosis, and/or autophagic cell death, such as accumulation of autophagosomes (Ref.)"
.
"Anti-angiogenesis (new blood vessels formation inhibitor): While going through a case report of a lady who ingested an extreme amount of silver particels experiencing argyria, I found interesting that all her blood analysis came out well, with the exception of the serum silver concentration that was 381 ng/ml (reference value <15 ng/ml) while her serum copper level was 24.8 mg/dl (normal range 70.0–155.0 mg/dl), and serum ceruloplasmin was 9.0 mg/dl (normal range 17.9–53.3 mg/dl). As we discussed here, Copper is essential for angiogenesis and tumor growth and Copper depleting treatments can be effective anti cancer treatments (Ref.). Indeed, after searching through the literature, I found more case reports where high ingestion of silver nanoparticles leads to copper and caeruloplasmin deficiency (Ref.1, Ref.2). This is why silver solutions may also be effective against ascites (Ref.)."
"Here I also found a paper reporting that Silver nanoparticles can act as an angiogenessis inhibitor, but the authors did not connect that with silver influence on copper metabolism but with HIF-1 modulation (Ref.). Digging further in literature we find that indeed it is known that Silver inhibits Copper transport (Ref.)."
.
"This is a similar effect as that of Tetrathiomolybdate www.cancertreatmentsresearch.com/tetrathiomolybdate-tm/, a Copper depleting substance with known anticancer effects. Actually Copper and Silver use the same transporter (CTR1 or copper transporter 1) when is absorbed in the body. And when used in higher amounts Silver is known to inhibit that www.sciencedirect.com/science/article/pii/S0946672X10000106 In turn, CTR1 silencing inhibits Angiogenesis by limiting copper entry into the cells journals.plos.org/plosone/article?id=10.1371/journal.pone.0071982"
.
"Autophagy disruption (Ref.)
.
Killing intratumoral bacteria – see explanation and references at the end of the Background section, above
.
Multi Drug Resistance (MDR1) inhibition to increase/enable effectiveness of chemotherapy (Ref.) – for this purpose, larger nano particles (about 75nm) are more efficient than the small ones
.
Inducing Endoplasmic reticulum (ER) stress (Ref.)
Toxicity and Side Effects
Research suggests that the generation of ROS is the mechanism underlying the cytotoxicity of silver nanoparticles (Ref.)."
"Silver was cleared from most organs after 8 weeks, but there is a longer retention of silver in brain and testis that should be considered in a risk assessment of silver nanoparticles (Ref.). Indeed, it has been shown that following the administration of silver nanoparticles, the anti-oxidant production inside the cells increases (via the activation of Nrf2 pathway – I discussed this pathway and its modulators sometimes ago here) (Ref.). On this line, if a patient uses high doses of Silver nanoparticles, he/she should be pay attention to the other pro-oxidant treatments used (such as chemo) since using more proxidant treatments at the same time may increase the risk of side effects.
Given the main mechanism leading to side effects indicated in the literature, I would always make sure to have strong anti oxidants at home, such as NAC (supplement available on-line) and use it if side effects are present during the use of silver nanoparticles.
Supplementation with Selenium or Vitamin E has been shown to increase the maximum acceptable exposure to silver (Ref.)."
pubmed.ncbi.nlm.nih.gov/23811290/
6.8µg/kg dose seems to be a safe dose.
I took colloidal silver regularly for about a week and then once to twice weekly.
I also took Vitamin E with Selenium daily. 268 mg SID
I think the antibacterial effects should not be overlooked on silver also.
www.nature.com/articles/srep14554
Zinc- 30 mg SID And I utilized zinc to promote natural killer cell immunity.
pubmed.ncbi.nlm.nih.gov/20155630/
Vitamin A- 1500 mcg (5000 IU) SID
Immune support
Vitamin K2 I took 100 mcg SID
pubmed.ncbi.nlm.nih.gov/29805627/
B Complex- I took twice recommended daily dosage as excess will be eliminated like Vitamin C.
Immune system function
CBD- full spectrum 1500 mg CBD SID
Cannabinoid system is overlooked. Has primary effect on cancer cells, controls nausea, reduced inflammation.
pubmed.ncbi.nlm.nih.gov/30627539/
